Originally submitted at SellNSend

The Lowepro Fastpack 350 will adapt to your ever changing requirements! The Fastpack 350 is a Backpack for your D-SLR camera with lenses, flash and accessories and Laptop Case or Bag for your Laptop or Notebook Computer with screen up to 17 inches. The Fastpack 350 is made from a tough, water-resis...
Good camera + laptop combo backpack
Pros: Comfortable, Adjustable Harness, Easily Accessible Equipment
Cons: Heavy, Cumbersome
Best Uses: Transporting Gear
Describe Yourself: Photo Enthusiast
Was this a gift?: No
I tried Lowepro FastPack 250 and found some of its lens 'rooms' are too narrow, therefore I bought FastPack 350 for my airplane (carry-on) and cruise trip. Like the 350 harness. The 350 seems a little bulky, a little hard to rotate from back to sling to pull out the camera. Wish 250 has larger lens rooms, or 350 is a little smaller. Will try this 350 on my airplane/cruise trip.
Another choice is Tamrac 3385 with rain resistant zippers, its size seems good, but I saw broken zipper on a store sample. :(
(legalese)